Protein Details: Voltage-gated potassium channel subunit beta-2
Protein ID
ICDB_Pro_0821
Protein Name
Voltage-gated potassium channel subunit beta-2
Gene Name
KCNAB2; KCNA2B; KCNK2
Organism
Homo sapiens (Human)
Length
367 amino acids
AlphaFoldDB
AF-Q13303-F1-model_v4.pdb
Function
Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Contributes to the regulation of nerve signaling;and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane;and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore. Promotes KCNA4 channel closure. Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 channel activity (By similarity). Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal;9;10-phenanthrenequinone;prostaglandin J2;4-nitrobenzaldehyde;4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity)
Sequence
Ligand Binding
Binding Site
56;57;63;85;158;188;189;214;243;244;245;246;247;248;254;262;264;323;325;329;332
Disease
Chromosome 1P36 Deletion Syndrome and Brain Malformations With Or Without Urinary Tract Defects
Location
Detected in myelinated nerve fibers in the spinal cord; in the juxtaparanodal region of the nodes of Ranvier; but also in the paranodal region (PubMed:11086297). Detected in hippocampus (at protein level) (PubMed:21357749). Detected in hippocampus (PubMed:7649300).
DOI ID
10.1016/0014-5793(95)00785-8; 10.1038/ng1285; 10.1038/nature04727; 10.1101/gr.2596504; 10.1002/1096-9861(20000101)429:1<166::aid-cne13>3.0.co;2-y; 10.1074/jbc.m111465200; 10.1126/scisignal.2000007; 10.1126/science.1175371; 10.1186/1752-0509-5-17; 10.1083/jcb.201007113; 10.1073/pnas.1210303109; 10.1021/pr300630k; 10.1074/mcp.o113.027870; 10.1002/pmic.201400617
RefSeq
NP_001186789.1 [Q13303-1]; NP_001186790.1 [Q13303-1]; NP_001186791.1 [Q13303-3]; NP_001186792.1 [Q13303-4]; NP_003627.1 [Q13303-1]; NP_742128.1 [Q13303-2]; XP_005263571.1 [Q13303-2]; XP_011540623.1 [Q13303-5]; XP_011540624.1 [Q13303-5]